CS / EN
CZ‑OPENSCREEN
National Infrastructure for Chemical Biology
CZ-OPENSCREEN is a state-of-the-art infrastructure for chemical biology and genetics offering open access to potential users. Our mission is to identify new molecular probes and to develop new tools for the research of chemical compounds – candidates for the development of new potential therapeutics.
SERVICES
SERVICES
HTS & MS
PROFILING
MEDCHEM
CHEMINFO
HIGH-THROUGHPUT SCREENING
Provides comprehensive services encompassing the identification of biologically active compounds by screening of large compound libraries using biological assays and state-of-the-art technologies integrated in robotic systems.
ASSAYS MASS SPECTROMETRY COMPOUND LIBRARY EQUIPMENT
Development of high-throughput/high-content screening assays
APPLY
 High-throughput screening and analysis
APPLY
 High-content screening and analysis
APPLY
 Mass Spectrometry & High-throughput mass spectrometry
APPLY
CHEMOSENSITIVE PROFILING
Chemosensitive profiling provides systematic and detailed information about libraries of small compounds or extracts, (e.g.phenotypic changes, cytotoxic and antiproliferative properties), using an extensive panel of cell lines of various histological origin.
ASSAYS COMPOUND LIBRARY EQUIPMENT
Viability/Proliferation assays
APPLY
 Apoptosis/Cell Death
APPLY
 Cytotoxicity/Necrosis
APPLY
 Ca2+ mobilization
APPLY
MEDICINAL CHEMISTRY
Provides services focused on the synthesis, purification, and structural characterization of new organic compounds with targeted biological activity.
Re-synthesis of HTS hits/known compounds
APPLY
 Purification and structural characterisation
APPLY
 Synthesis of new analogues and SAR development
APPLY
 Support of IP protection
APPLY
CHEMINFORMATICS
The Cheminformatics core facilitates decision-making processes via innovative data visualization and analysis methods developed for medicinal and pharmaceutical research areas.
PROBES & DRUGS ECBD SCREENX
the support of assay development and of high throughput/high-content screening
APPLY
 databases and tools for compound registration and inventory, HTS plate formatting and tracking
APPLY
 the design of appropriate compound collections, SAR follow-up of hits and hit-to-lead optimization
APPLY
 in silico screening through ligand based virtual screening, docking and other molecular modelling approaches
APPLY
COMPOUND LIBRARIES
COMPOUND LIBRARIES
Chemical libraries (or compound collections/sets) are one of the essential components for research areas of chemical biology and medicinal chemistry. Chemical libraries are collections of small organic compounds, usable in drug discovery and other industrial processes.
217,000
DIVERSITY SETS
10,000
BIOACTIVES
7,000
INDUSTRIAL
10,600
ACADEMIC
3,000
NATURAL PRODUCTS
DIVERSITY SETS
~217,000 compounds
wide coverage of chemical space custom compiled sets of chemicals lead-like and drug-like compounds IP-free
Enamine Advanced Diversity set
10K
ChemBridge Diversity set
25K
Enamine Diversity set
45K
NCI Diversity II
1.4K
EU-OS ECBL Diversity set
99K
BIOACTIVES
~10,000 compounds
curated set of tool compounds, chemical probes, and drugs including precompiled commercial libraries from Sigma, Prestwick and Cayman Chemical (prostagnadins and fatty acids)
CZ-OPENSCREEN bioactive set
3.3K
EU-OPENSCREEN bioactive set
2.4K
COMMERCIAL SETS
4.1K
OTHER
~21,000 compounds
proprietary chemical substances donated by academic/commercial research groups commercially inaccessible chemistry
CZ academic chemistry collection
4.7K
EU academic chemistry collection
6.3K
Industrial chemistry collection
7.1K
Natural Products and Extracts
2.8K
ACCESS PRINCIPLES
ACCESS PRINCIPLES
CZ-OPENSCREEN provides the services either under open access policy or on the commercial basis, when user pays the full cost of the project. As part of open access cooperation, Material Transfer Agreement is concluded between CZ-OPENSCREEN and the user. Project accepted to the open access program is evaluated by the Open Access Committee.
PROJECT
APPLICATION
OPEN ACCESS
COLLABORATION
FEE FOR SERVICE
PROCESS
User
Open access
Project application
Collaboration
Negotiation / Grant proposal
Fee for service
Expression of interest
CZ-OPENSCREEN
Open access
Project evaluation by OA committee
Collaboration
Negotiation / Grant proposal
Fee for service
Preliminary quote
COSTS
Consumables
Open access
not covered
Collaboration
shared
Fee for service
not covered
Access to tech + FTE
Open access
covered
Collaboration
shared
Fee for service
not covered
Access to compounds
Open access
covered *
Collaboration
shared
Fee for service
not covered
LEGAL
IP
Open access
shared
Collaboration
shared
Fee for service
user-owned
Data protection
Open access
Max. 3 years embargo period
Collaboration
negotiable
Fee for service
CDA / proprietary
Contract
Open access
Open Access contract
Collaboration
Grants / Collaborative contracts
Fee for service
Commercial contract
*Access to EU-OPENSCREEN libraries is not covered within open access projects
PROJECTS
PROJECTS