CS / EN
The CZ-OPENSCREEN compound library was recently enhanced by including 9,944 of novel high-quality chemical compounds of the Advanced Diversity Set(selected from the Enamine's Advanced Diversity Library). The collection contains premium small molecules with lead-like properties (molecular ≤ 350, cLogP ≤ 3, and rotatable bonds ≤ 7 and/or valuable pharmacophores suc as carboxylic, primary amino and amide groups). The library is specific for representing synthetically new and unique chemotypes with sp3-rich molecular scaffolds, which are likely to interact with hardly druggable biological targets.
On February 21st, we attended the 1st Czech Cheminformatics Meeting organized by Daniel Svozil (UCT Prague) and Pavel Polishchuk (IMTM Olomouc) at UCT Prague. At this one day meeting, group leaders of cheminformatics-focused groups presented the research topics carried out in Czech Republic. The keynote lecture on "Molecular cartography application to Big Data visualization and analysis" was given by prof. Alexandre Varnek from the University of Strasbourg.
New website of the infrastracture has been launched, containing all essential information about the technology and know-how at the infrastructure. Please, use the contact form to get in touch with us!
Next week, we will attend the ELRIG´S THERAPEUTIC OLIGOS & EUROPEAN CHEMICAL BIOLOGY SYMPOSIUM 2023 (ECBS2023) in Gothenburg, Sweden, co-organized by ELRIG and EU-OPENSCREEN/EuChemS, and hosted by AstraZeneca R&D site. The conference will focus on topics like Therapeutic OLIGO profiling, Advancements in OLIGO design and synthesis, Novel formulations and biomarker analysis, Chemical probe-induced protein interaction and degradation, New ways to shape and interrogate biology through chemistry, and innovative tools and methods for advanced cell profiling.
Next week on 24th of May, we are going to present the Probes & Drugs portal at the prestigious conference Modern phenotypic drug discovery: From chemical biology to therapeutics in Denver, Colorado, organized by the Keystone Symposia on Molecular and Cellular Biology organization. In a short talk, we are going to present the current state of the portal under the title Probes & Drugs portal in 2022: A hub for the integration of high-quality bioactive compound sets, followed by a poster with the same name.
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Abramova V, Leal Alvarado V, Hill M, Smejkalova T, Maly M, Vales K, Dittert I, Bozikova P, Kysilov B, Hrcka Krausova B, Vyklicky V, Balik A, Fili K, Korinek M, Chodounska H, Kudova E, Ciz D, Martinovic J, Cerny J, Bartunek P, Vyklicky L. Effects of Pregnanolone Glutamate and Its Metabolites on GABAA and NMDA Receptors and Zebrafish Behavior. ACS Chem Neurosci. 2023 May 17;14(10):1870-1883. doi: 10.1021/acschemneuro.3c00131. Epub 2023 May 1. PMID: 37126803; PMCID: PMC10198160.
Demkova L, Bugajev V, Utekal P, Kuchar L, Schuster B, Draber P, Halova I. Simultaneous reduction of all ORMDL proteins decreases the threshold of mast cell activation. Sci Rep. 2023 Jun 14;13(1):9615. doi: 10.1038/s41598-023-36344-5. PMID: 37316542; PMCID: PMC10267218.
Bugajev V, Draberova L, Utekal P, Blazikova M, Tumova M, Draber P. Enhanced Membrane Fluidization and Cholesterol Displacement by 1-Heptanol Inhibit Mast Cell Effector Functions. Cells. 2023 Aug 15;12(16):2069. doi: 10.3390/cells12162069. PMID: 37626879; PMCID: PMC10453462.
Hruba L, Das V, Hajduch M, Dzubak P. Nucleoside-based anticancer drugs: Mechanism of action and drug resistance. Biochem Pharmacol. 2023 Sep;215:115741. doi: 10.1016/j.bcp.2023.115741. Epub 2023 Aug 9. PMID: 37567317.
Ivasechko I, Lozynskyi A, Senkiv J, Roszczenko P, Kozak Y, Finiuk N, Klyuchivska O, Kashchak N, Manko N, Maslyak Z, Lesyk D, Karkhut A, Polovkovych S, Czarnomysy R, Szewczyk O, Kozytskiy A, Karpenko O, Khyluk D, Gzella A, Bielawski K, Bielawska A, Dzubak P, Gurska S, Hajduch M, Stoika R, Lesyk R. Molecular design, synthesis and anticancer activity of new thiopyrano[2,3-d]thiazoles based on 5-hydroxy-1,4-naphthoquinone (juglone). Eur J Med Chem. 2023 Apr 5;252:115304. doi: 10.1016/j.ejmech.2023.115304. Epub 2023 Mar 24. PMID: 37001390.
Rajan K, Brinkhaus HO, Agea MI, Zielesny A, Steinbeck C. DECIMER.ai: an open platform for automated optical chemical structure identification, segmentation and recognition in scientific publications. Nat Commun. 2023 Aug 19;14(1):5045. doi: 10.1038/s41467-023-40782-0. PMID: 37598180; PMCID: PMC10439916.
Šícho M, Luukkonen S, van den Maagdenberg HW, Schoenmaker L, Béquignon OJM, van Westen GJP. DrugEx: Deep Learning Models and Tools for Exploration of Drug-Like Chemical Space. J Chem Inf Model. 2023 Jun 26;63(12):3629-3636. doi: 10.1021/acs.jcim.3c00434. Epub 2023 Jun 5. PMID: 37272707; PMCID: PMC10306259.
Němec V, Khirsariya P, Janovská P, Moyano PM, Maier L, Procházková P, Kebková P, Gybel' T, Berger BT, Chaikuad A, Reinecke M, Kuster B, Knapp S, Bryja V, Paruch K. Discovery of Potent and Exquisitely Selective Inhibitors of Kinase CK1 with Tunable Isoform Selectivity. Angew Chem Int Ed Engl. 2023 Mar 6;62(11):e202217532. doi: 10.1002/anie.202217532. Epub 2023 Feb 2. PMID: 36625768.
Hason M, Jovicic J, Vonkova I, Bojic M, Simon-Vermot T, White RM, Bartunek P. Bioluminescent Zebrafish Transplantation Model for Drug Discovery. Front Pharmacol. 2022 Apr 27;13:893655. doi: 10.3389/fphar.2022.893655. PMID: 35559262; PMCID: PMC9086674.
Králová J, Popr M, Valečka J, Bartůněk P. Sterolight as imaging tool to study sterol uptake, trafficking and efflux in living cells. Sci Rep. 2022 Apr 15;12(1):6264. doi: 10.1038/s41598-022-10134-x. PMID: 35428843; PMCID: PMC9012876.
Delawská K, Divoká P, Sedlák D, Kuzma M, Saurav K, Macho M, Steinbach G, Hrouzek P. New Insights into Tolytoxin Effect in Human Cancer Cells: Apoptosis Induction and the Relevance of Hydroxyl Substitution of Its Macrolide Cycle on Compound Potency. Chembiochem. 2022 Jan 5;23(1):e202100489. doi: 10.1002/cbic.202100489. Epub 2021 Dec 9. PMID: 34821450.
Hason M, Mikulasova T, Machonova O, Pombinho A, van Ham TJ, Irion U, Nüsslein-Volhard C, Bartunek P, Svoboda O. M-CSFR/CSF1R signaling regulates myeloid fates in zebrafish via distinct action of its receptors and ligands. Blood Adv. 2022 Mar 8;6(5):1474-1488. doi: 10.1182/bloodadvances.2021005459. PMID: 34979548; PMCID: PMC8905693.
Rysanek D, Vasicova P, Kolla JN, Sedlak D, Andera L, Bartek J, Hodny Z. Synergism of BCL-2 family inhibitors facilitates selective elimination of senescent cells. Aging (Albany NY). 2022 Aug 8;14(16):6381-6414. doi: 10.18632/aging.204207. Epub 2022 Aug 8. PMID: 35951353; PMCID: PMC9467395.
Hadrava Vanova K, Pang Y, Krobova L, Kraus M, Nahacka Z, Boukalova S, Pack SD, Zobalova R, Zhu J, Huynh TT, Jochmanova I, Uher O, Hubackova S, Dvorakova S, Garrett TJ, Ghayee HK, Wu X, Schuster B, Knapp PE, Frysak Z, Hartmann I, Nilubol N, Cerny J, Taieb D, Rohlena J, Neuzil J, Yang C, Pacak K. Germline SUCLG2 Variants in Patients With Pheochromocytoma and Paraganglioma. J Natl Cancer Inst. 2022 Jan 11;114(1):130-138. doi: 10.1093/jnci/djab158. PMID: 34415331; PMCID: PMC8755484.
Ćavar Zeljković S, Schadich E, Džubák P, Hajdúch M, Tarkowski P. Antiviral Activity of Selected Lamiaceae Essential Oils and Their Monoterpenes Against SARS-Cov-2. Front Pharmacol. 2022 May 2;13:893634. doi: 10.3389/fphar.2022.893634. PMID: 35586050; PMCID: PMC9108200.
Kotulova J, Lonova K, Kubickova A, Vrbkova J, Kourilova P, Hajduch M, Dzubak P. 2‑Cl‑IB‑MECA regulates the proliferative and drug resistance pathways, and facilitates chemosensitivity in pancreatic and liver cancer cell lines. Int J Mol Med. 2022 Mar;49(3):31. doi: 10.3892/ijmm.2022.5086. Epub 2022 Jan 18. PMID: 35039871; PMCID: PMC8788926.
Hruba L, Polishchuk P, Das V, Hajduch M, Dzubak P. An identification of MARK inhibitors using high throughput MALDI-TOF mass spectrometry. Biomed Pharmacother. 2022 Feb;146:112549. doi: 10.1016/j.biopha.2021.112549. Epub 2021 Dec 16. PMID: 34923338.
Baručić D, Kaushik S, Kybic J, Stanková J, Džubák P, Hajdúch M. Characterization of drug effects on cell cultures from phase-contrast microscopy images. Comput Biol Med. 2022 Dec;151(Pt A):106171. doi: 10.1016/j.compbiomed.2022.106171. Epub 2022 Oct 14. PMID: 36306582.
Gutiérrez JE, Fernandez-Moreira E, Rodríguez MA, Mijares MR, De Sanctis JB, Gurská S, Džubák P, Hajdůch M, Bruno-Colmenarez J, Rojas L, Deffieux D, Pouységu L, Quideau S, Charris J, Ramírez H. Novel 7-Chloro-(4-thioalkylquinoline) Derivatives: Synthesis and Antiproliferative Activity through Inducing Apoptosis and DNA/RNA Damage. Pharmaceuticals (Basel). 2022 Oct 8;15(10):1234. doi: 10.3390/ph15101234. PMID: 36297346; PMCID: PMC9607427.
Yang C, Slavětínská LP, Fleuti M, Klepetářová B, Tichý M, Gurská S, Pavliš P, Džubák P, Hajdúch M, Hocek M. Synthesis of Polycyclic Hetero-Fused 7-Deazapurine Heterocycles and Nucleosides through C-H Dibenzothiophenation and Negishi Coupling. J Am Chem Soc. 2022 Oct 26;144(42):19437-19446. doi: 10.1021/jacs.2c07517. Epub 2022 Oct 16. PMID: 36245092; PMCID: PMC9619403.
Vrzalová A, Pečinková P, Illés P, Gurská S, Džubák P, Szotkowski M, Hajdúch M, Mani S, Dvořák Z. Mixture Effects of Tryptophan Intestinal Microbial Metabolites on Aryl Hydrocarbon Receptor Activity. Int J Mol Sci. 2022 Sep 16;23(18):10825. doi: 10.3390/ijms231810825. PMID: 36142735; PMCID: PMC9505659.
Rehulka J, Subtelna I, Kryshchyshyn-Dylevych A, Cherniienko A, Ivanova A, Matveieva M, Polishchuk P, Gurska S, Hajduch M, Zagrijtschuk O, Dzubak P, Lesyk R. Anticancer 5-arylidene-2-(4-hydroxyphenyl)aminothiazol-4(5H)-ones as tubulin inhibitors. Arch Pharm (Weinheim). 2022 Dec;355(12):e2200419. doi: 10.1002/ardp.202200419. Epub 2022 Sep 15. PMID: 36109178.
Schadich E, Nylén S, Gurská S, Kotulová J, Andronati S, Pavlovsky V, Soboleva S, Polishchuk P, Hajdúch M, Džubák P. Activity of 1-aryl-4-(naphthalimidoalkyl) piperazine derivatives against Leishmania major and Leishmania mexicana. Parasitol Int. 2022 Dec;91:102647. doi: 10.1016/j.parint.2022.102647. Epub 2022 Aug 17. PMID: 35985636.
Jurášek M, Řehulka J, Hrubá L, Ivanová A, Gurská S, Mokshyna O, Trousil P, Huml L, Polishchuk P, Hajdúch M, Drašar PB, Džubák P. Triazole-based estradiol dimers prepared via CuAAC from 17α-ethinyl estradiol with five-atom linkers causing G2/M arrest and tubulin inhibition. Bioorg Chem. 2023 Feb;131:106334. doi: 10.1016/j.bioorg.2022.106334. Epub 2022 Dec 23. PMID: 36592487.
Tumova S, Milacek M, Šnajdr I, Muthu M, Tuma R, Reha D, Jedlicka P, Bittova L, Novotna A, Majer P, Sedlak D, Jindra M. Unique peptidic agonists of a juvenile hormone receptor with species-specific effects on insect development and reproduction. Proc Natl Acad Sci U S A. 2022 Nov 29;119(48):e2215541119. doi: 10.1073/pnas.2215541119. Epub 2022 Nov 21. PMID: 36409882.
Souckova O, Skopova V, Baresova V, Sedlak D, Bleyer AJ, Kmoch S, Zikanova M. Metabolites of De Novo Purine Synthesis: Metabolic Regulators and Cytotoxic Compounds. Metabolites. 2022 Dec 2;12(12):1210. doi: 10.3390/metabo12121210. PMID: 36557247; PMCID: PMC9788633.
Bubanová D, Fučíková AM, Majláth I, Pajer P, Bjelková K, Majláthová V. The first detection of relapsing fever spirochete Borrelia miyamotoi in Ixodes ricinus ticks from the northeast Czech Republic. Ticks Tick Borne Dis. 2022 Sep 13;13(6):102042. doi: 10.1016/j.ttbdis.2022.102042. Epub ahead of print. PMID: 36126494.
Blanco Z, Fernandez-Moreira E, Mijares MR, Celis C, Martínez G, De Sanctis JB, Gurská S, Džubák P, Hajdůch M, Mijoba A, García Y, Serrano X, Herrera N, Correa-Abril J, Parra Y, Ángel J, Ramírez H, Charris JE. Synthesis, Leishmanicidal, Trypanocidal, Antiproliferative Assay and Apoptotic Induction of (2-Phenoxypyridin-3-yl)naphthalene-1(2H)-one Derivatives. Molecules. 2022 Aug 31;27(17):5626. doi: 10.3390/molecules27175626. PMID: 36080388; PMCID: PMC9457600.
Juza R, Vojtechova I, Stefkova-Mazochova K, Dehaen W, Petrasek T, Prchal L, Kobrlova T, Janousek J, Vlcek P, Mezeiova E, Svozil D, Karasova JZ, Pejchal J, Stark H, Satala G, Bojarski AJ, Kubacka M, Mogilski S, Randakova A, Musilek K, Soukup O, Korabecny J. Novel D2/5-HT receptor modulators related to cariprazine with potential implication to schizophrenia treatment. Eur J Med Chem. 2022 Mar 15;232:114193. doi: 10.1016/j.ejmech.2022.114193. Epub 2022 Feb 9. PMID: 35176563.
Prihoda D, Maamary J, Waight A, Juan V, Fayadat-Dilman L, Svozil D, Bitton DA. BioPhi: A platform for antibody design, humanization, and humanness evaluation based on natural antibody repertoires and deep learning. MAbs. 2022 Jan-Dec;14(1):2020203. doi: 10.1080/19420862.2021.2020203. PMID: 35133949; PMCID: PMC8837241.
Štefková-Mazochová K, Danda H, Dehaen W, Jurásek B, Šíchová K, Pinterová-Leca N, Mazoch V, Krausová BH, Kysilov B, Smejkalová T, Vyklický L, Kohout M, Hájková K, Svozil D, Horsley RR, Kuchař M, Páleníček T. Pharmacokinetic, pharmacodynamic, and behavioural studies of deschloroketamine in Wistar rats. Br J Pharmacol. 2022 Jan;179(1):65-83. doi: 10.1111/bph.15680. Epub 2021 Oct 31. PMID: 34519023.
Tharra PR, Mikhaylov AA, Švejkar J, Gysin M, Hobbie SN, Švenda J. Short Synthesis of (+)-Actinobolin: Simple Entry to Complex Small-Molecule Inhibitors of Protein Synthesis. Angew Chem Int Ed Engl. 2022 Apr 19;61(17):e202116520. doi: 10.1002/anie.202116520. Epub 2022 Feb 28. PMID: 35167723.
Khirsariya P, Pospíšil P, Maier L, Boudný M, Babáš M, Kroutil O, Mráz M, Vácha R, Paruch K. Synthesis and Profiling of Highly Selective Inhibitors of Methyltransferase DOT1L Based on Carbocyclic C-Nucleosides. J Med Chem. 2022 Apr 14;65(7):5701-5723. doi: 10.1021/acs.jmedchem.1c02228. Epub 2022 Mar 18. PMID: 35302777.
Szczepanik PM, Mikhaylov AA, Hylse O, Kučera R, Daďová P, Nečas M, Kubala L, Paruch K, Švenda J. Convergent Assembly of the Tricyclic Labdane Core Enables Synthesis of Diverse Forskolin-like Molecules. Angew Chem Int Ed Engl. 2023 Jan 2;62(1):e202213183. doi: 10.1002/anie.202213183. Epub 2022 Nov 29. PMID: 36321750.
Hluchý M, Gajdušková P, Ruiz de Los Mozos I, Rájecký M, Kluge M, Berger BT, Slabá Z, Potěšil D, Weiß E, Ule J, Zdráhal Z, Knapp S, Paruch K, Friedel CC, Blazek D. CDK11 regulates pre-mRNA splicing by phosphorylation of SF3B1. Nature. 2022 Sep;609(7928):829-834. doi: 10.1038/s41586-022-05204-z. Epub 2022 Sep 14. PMID: 36104565.
Attuluri VPS, Sánchez López JF, Maier L, Paruch K, Robert HS. Comparing the efficiency of six clearing methods in developing seeds of Arabidopsis thaliana. Plant Reprod. 2022 Dec;35(4):279-293. doi: 10.1007/s00497-022-00453-4. Epub 2022 Nov 15. PMID: 36378346; PMCID: PMC9705463.
Pospíšil J, Hrabovský M, Bohačiaková D, Hovádková Z, Jurásek M, Mlčoušková J, Paruch K, Nevolová Š, Damborsky J, Hampl A, Jaros J. Geometric Control of Cell Behavior by Biomolecule Nanodistribution. ACS Biomater Sci Eng. 2022 Nov 14;8(11):4789-4806. doi: 10.1021/acsbiomaterials.2c00650. Epub 2022 Oct 6. PMID: 36202388; PMCID: PMC9667466.
Khirsariya P, Pospíšil P, Maier L, Boudný M, Babáš M, Kroutil O, Mráz M, Vácha R, Paruch K. Synthesis and Profiling of Highly Selective Inhibitors of Methyltransferase DOT1L Based on Carbocyclic C-Nucleosides. J Med Chem. 2022 Apr 14;65(7):5701-5723. doi: 10.1021/acs.jmedchem.1c02228. Epub 2022 Mar 18. PMID: 35302777.
Kameda-Smith MM, Zhu H, Luo EC, Suk Y, Xella A, Yee B, Chokshi C, Xing S, Tan F, Fox RG, Adile AA, Bakhshinyan D, Brown K, Gwynne WD, Subapanditha M, Miletic P, Picard D, Burns I, Moffat J, Paruch K, Fleming A, Hope K, Provias JP, Remke M, Lu Y, Reya T, Venugopal C, Reimand J, Wechsler-Reya RJ, Yeo GW, Singh SK. Characterization of an RNA binding protein interactome reveals a context-specific post-transcriptional landscape of MYC-amplified medulloblastoma. Nat Commun. 2022 Dec 6;13(1):7506. doi: 10.1038/s41467-022-35118-3. Erratum in: Nat Commun. 2023 Jan 10;14(1):136. PMID: 36473869; PMCID: PMC9726987.
Sedlák D, Wilson TA, Tjarks W, Radomska HS, Wang H, Kolla JN, Leśnikowski ZJ, Špičáková A, Ali T, Ishita K, Rakotondraibe LH, Vibhute S, Wang D, Anzenbacher P, Bennett C, Bartunek P, Coss CC. Structure-Activity Relationship of para-Carborane Selective Estrogen Receptor β Agonists. J Med Chem. 2021 Jul 8;64(13):9330-9353. doi: 10.1021/acs.jmedchem.1c00555.
Delawská K, Divoká P, Sedlák D, Kuzma M, Saurav K, Macho M, Steinbach G, Hrouzek P. New Insights into Tolytoxin Effect in Human Cancer Cells: Apoptosis Induction and the Relevance of Hydroxyl Substitution of Its Macrolide Cycle on Compound Potency. Chembiochem. 2021 Nov 25. doi: 10.1002/cbic.202100489.
Švecová L, Østergaard LH, Skálová T, Schnorr KM, Koval' T, Kolenko P, Stránský J, Sedlák D, Dušková J, Trundová M, Hašek J, Dohnálek J. Crystallographic fragment screening-based study of a novel FAD-dependent oxidoreductase from Chaetomium thermophilum. Acta Crystallogr D Struct Biol. 2021 Jun 1;77(Pt 6):755-775. doi: 10.1107/S2059798321003533. Epub 2021 May 14. Erratum in: Acta Crystallogr D Struct Biol. 2021 Jul 1;77(Pt 7):980-981.
Švecová L, Østergaard LH, Skálová T, Schnorr KM, Koval' T, Kolenko P, Stránský J, Sedlák D, Dušková J, Trundová M, Hašek J, Dohnálek J. Crystallographic fragment screening-based study of a novel FAD-dependent oxidoreductase from Chaetomium thermophilum. Corrigendum. Acta Crystallogr D Struct Biol. 2021 Jul 1;77(Pt 7):980-981. doi: 10.1107/S2059798321006100. Epub 2021 Jun 18. Erratum for: Acta Crystallogr D Struct Biol. 2021 Jun 1;77(Pt 6):755-775.
Jurášek M, Valečka J, Novotný I, Kejík Z, Fähnrich J, Marešová A, Tauchen J, Bartůněk P, Dolenský B, Jakubek M, Drašar PB, Králová J. Synthesis and biological evaluation of cationic TopFluor cholesterol analogues. Bioorg Chem. 2021 Dec;117:105410. doi: 10.1016/j.bioorg.2021.105410.
Škuta C, Southan C, Bartůněk P. Will the chemical probes please stand up? RSC Med Chem. 2021 Jul 16;12(8):1428-1441. doi: 10.1039/d1md00138h.
Kejík Z, Kaplánek R, Dytrych P, Masařík M, Veselá K, Abramenko N, Hoskovec D, Vašáková M, Králová J, Martásek P, Jakubek M. Circulating Tumour Cells (CTCs) in NSCLC: From Prognosis to Therapy Design. Pharmaceutics. 2021 Nov 5;13(11):1879. doi: 10.3390/pharmaceutics13111879.
Buchtova T, Skrott Z, Chroma K, Rehulka J, Dzubak P, Hajduch M, Lukac D, Arampatzis S, Bartek J, Mistrik M. Cannabidiol-induced activation of the metallothionein pathway impedes anticancer effects of disulfiram and its metabolite CuET. Mol Oncol. 2021 Oct 10. doi: 10.1002/1878-0261.13114.
Hruba L, Polishchuk P, Das V, Hajduch M, Dzubak P. An identification of MARK inhibitors using high throughput MALDI-TOF mass spectrometry. Biomed Pharmacother. 2021 Dec 16;146:112549. doi: 10.1016/j.biopha.2021.112549.
Kodr D, Stanková J, Rumlová M, Džubák P, Řehulka J, Zimmermann T, Křížová I, Gurská S, Hajdúch M, Drašar PB, Jurášek M. Betulinic Acid Decorated with Polar Groups and Blue Emitting BODIPY Dye: Synthesis, Cytotoxicity, Cell-Cycle Analysis and Anti-HIV Profiling. Biomedicines. 2021 Aug 28;9(9):1104. doi: 10.3390/biomedicines9091104.
Kotulová J, Hajdúch M, Džubák P. Current Adenosinergic Therapies: What Do Cancer Cells Stand to Gain and Lose? Int J Mol Sci. 2021 Nov 22;22(22):12569. doi: 10.3390/ijms222212569.
Pokorný J, Olejníková D, Frydrych I, Lišková B, Gurská S, Benická S, Šarek J, Kotulová J, Hajdúch M, Džubák P, Urban M. Substituted dienes prepared from betulinic acid - Synthesis, cytotoxicity, mechanism of action, and pharmacological parameters. Eur J Med Chem. 2021 Nov 15;224:113706. doi: 10.1016/j.ejmech.2021.113706.
Porubský M, Gurská S, Stanková J, Hajdúch M, Džubák P, Hlaváč J. AminoBODIPY Conjugates for Targeted Drug Delivery Systems and Real-Time Monitoring of Drug Release. Mol Pharm. 2021 Jun 7;18(6):2385-2396. doi: 10.1021/acs.molpharmaceut.1c00219.
Porubský M, Vychodilová K, Milićević D, Buděšinský M, Stanková J, Džubák P, Hajdúch M, Hlaváč J. Cytotoxicity of Amino-BODIPY Modulated via Conjugation with 2-Phenyl-3-Hydroxy-4(1H)-Quinolinones. ChemistryOpen. 2021 Nov;10(11):1104-1110. doi: 10.1002/open.202100025.
Raffaele M, Kovacovicova K, Biagini T, Lo Re O, Frohlich J, Giallongo S, Nhan JD, Giannone AG, Cabibi D, Ivanov M, Tonchev AB, Mistrik M, Lacey M, Dzubak P, Gurska S, Hajduch M, Bartek J, Mazza T, Micale V, Curran SP, Vinciguerra M. Nociceptin/orphanin FQ opioid receptor (NOP) selective ligand MCOPPB links anxiolytic and senolytic effects. Geroscience. 2021 Nov 24:1–21. doi: 10.1007/s11357-021-00487-y.
Rimpelová S, Zimmermann T, Drašar PB, Dolenský B, Bejček J, Kmoníčková E, Cihlářová P, Gurská S, Kuklíková L, Hajdúch M, Ruml T, Opletal L, Džubák P, Jurášek M. Steroid Glycosides Hyrcanoside and Deglucohyrcanoside: On Isolation, Structural Identification, and Anticancer Activity. Foods. 2021 Jan 11;10(1):136. doi: 10.3390/foods10010136.
Jurásek B, Čmelo I, Svoboda J, Čejka J, Svozil D, Kuchař M. New psychoactive substances on dark web markets: From deal solicitation to forensic analysis of purchased substances. Drug Test Anal. 2021 Jan;13(1):156-168. doi: 10.1002/dta.2901.
Juza R, Stefkova K, Dehaen W, Randakova A, Petrasek T, Vojtechova I, Kobrlova T, Pulkrabkova L, Muckova L, Mecava M, Prchal L, Mezeiova E, Musilek K, Soukup O, Korabecny J. Synthesis and In Vitro Evaluation of Novel Dopamine Receptor D2 3,4-dihydroquinolin-2(1H)-one Derivatives Related to Aripiprazole. Biomolecules. 2021 Aug 24;11(9):1262. doi: 10.3390/biom11091262.
Čmelo I, Voršilák M, Svozil D. Profiling and analysis of chemical compounds using pointwise mutual information. J Cheminform. 2021 Jan 10;13(1):3. doi: 10.1186/s13321-020-00483-y.
de Bruyn Kops C, Šícho M, Mazzolari A, Kirchmair J. GLORYx: Prediction of the Metabolites Resulting from Phase 1 and Phase 2 Biotransformations of Xenobiotics. Chem Res Toxicol. 2021 Feb 15;34(2):286-299. doi: 10.1021/acs.chemrestox.0c00224.
Plonka W, Stork C, Šícho M, Kirchmair J. CYPlebrity: Machine learning models for the prediction of inhibitors of cytochrome P450 enzymes. Bioorg Med Chem. 2021 Sep 15;46:116388. doi: 10.1016/j.bmc.2021.116388.
Sicho M, Liu X, Svozil D, van Westen GJP. GenUI: interactive and extensible open source software platform for de novo molecular generation and cheminformatics. J Cheminform. 2021 Sep 25;13(1):73. doi: 10.1186/s13321-021-00550-y.
Wilm A, Norinder U, Agea MI, de Bruyn Kops C, Stork C, Kühnl J, Kirchmair J. Skin Doctor CP: Conformal Prediction of the Skin Sensitization Potential of Small Organic Molecules. Chem Res Toxicol. 2021 Feb 15;34(2):330-344. doi: 10.1021/acs.chemrestox.0c00253.
Maryška M, Svobodová L, Dehaen W, Hrabinová M, Rumlová M, Soukup O, Kuchař M. Heterocyclic Cathinones as Inhibitors of Kynurenine Aminotransferase II-Design, Synthesis, and Evaluation. Pharmaceuticals (Basel). 2021 Dec 10;14(12):1291. doi: 10.3390/ph14121291. PMID: 34959692; PMCID: PMC8708382.
Maková B, Mik V, Lišková B, Gonzalez G, Vítek D, Medvedíková M, Monfort B, Ručilová V, Kadlecová A, Khirsariya P, Gándara Barreiro Z, Havlíček L, Zatloukal M, Soural M, Paruch K, D'Autréaux B, Hajdúch M, Strnad M, Voller J. Cytoprotective activities of kinetin purine isosteres. Bioorg Med Chem. 2021 Mar 1;33:115993. doi: 10.1016/j.bmc.2021.115993.
Němec V, Maier L, Berger BT, Chaikuad A, Drápela S, Souček K, Knapp S, Paruch K. Highly selective inhibitors of protein kinases CLK and HIPK with the furo[3,2-b]pyridine core. Eur J Med Chem. 2021 Apr 5;215:113299. doi: 10.1016/j.ejmech.2021.113299.
Jachak GR, Tharra PR, Sevelda P, Švenda J. Stereocontrolled Synthesis of Pseurotin A2. J Org Chem. 2021 Sep 3;86(17):11845-11861. doi: 10.1021/acs.joc.1c01152.
Králová J, Jurášek M, Mikšátková L, Marešová A, Fähnrich J, Cihlářová P, Drašar P, Bartůněk P, Král V. Influence of fluorophore and linker length on the localization and trafficking of fluorescent sterol probes. Sci Rep. 2020 Dec 16;10(1):22053. doi: 10.1038/s41598-020-78085-9.
Škuta C, Cortés-Ciriano I, Dehaen W, Kříž P, van Westen GJP, Tetko IV, Bender A, Svozil D. QSAR-derived affinity fingerprints (part 1): fingerprint construction and modeling performance for similarity searching, bioactivity classification and scaffold hopping. J Cheminform. 2020 May 29;12(1):39. doi: 10.1186/s13321-020-00443-6.
Cortés-Ciriano I, Škuta C, Bender A, Svozil D. QSAR-derived affinity fingerprints (part 2): modeling performance for potency prediction. J Cheminform. 2020 Jun 5;12(1):41. doi: 10.1186/s13321-020-00444-5.
Borková L, Frydrych I, Jakubcová N, Adámek R, Lišková B, Gurská S, Medvedíková M, Hajdúch M, Urban M. Synthesis and biological evaluation of triterpenoid thiazoles derived from betulonic acid, dihydrobetulonic acid, and ursonic acid. Eur J Med Chem. 2020 Jan 1;185:111806. doi: 10.1016/j.ejmech.2019.111806.
Řehulka J, Vychodilová K, Krejčí P, Gurská S, Hradil P, Hajdúch M, Džubák P, Hlaváč J. Fluorinated derivatives of 2-phenyl-3-hydroxy-4(1H)-quinolinone as tubulin polymerization inhibitors. Eur J Med Chem. 2020 Apr 15;192:112176. doi: 10.1016/j.ejmech.2020.112176.
Schadich E, Kryshchyshyn-Dylevych A, Holota S, Polishchuk P, Džubak P, Gurska S, Hajduch M, Lesyk R. Assessing different thiazolidine and thiazole based compounds as antileishmanial scaffolds. Bioorg Med Chem Lett. 2020 Dec 1;30(23):127616. doi: 10.1016/j.bmcl.2020.127616.
Džubák P, Gurská S, Bogdanová K, Uhríková D, Kanjaková N, Combet S, Klunda T, Kolář M, Hajdúch M, Poláková M. Antimicrobial and cytotoxic activity of (thio)alkyl hexopyranosides, nonionic glycolipid mimetics. Carbohydr Res. 2020 Feb;488:107905. doi: 10.1016/j.carres.2019.107905.
Stork C, Embruch G, Šícho M, de Bruyn Kops C, Chen Y, Svozil D, Kirchmair J. NERDD: a web portal providing access to in silico tools for drug discovery. Bioinformatics. 2020 Feb 15;36(4):1291-1292. doi: 10.1093/bioinformatics/btz695.
Jurásek B, Bartůněk V, Huber Š, Fagan P, Setnička V, Králík F, Dehaen W, Svozil D, Kuchař M. Can X-Ray Powder Diffraction Be a Suitable Forensic Method for Illicit Drug Identification? Front Chem. 2020 Jun 23;8:499. doi: 10.3389/fchem.2020.00499.
Voršilák M, Kolář M, Čmelo I, Svozil D. SYBA: Bayesian estimation of synthetic accessibility of organic compounds. J Cheminform. 2020 May 20;12(1):35. doi: 10.1186/s13321-020-00439-2.
Jurásek B, Čmelo I, Hájková K, Kofroňová E, Kuchař M. Counterfeit benzodiazepines-A phantom menace. Int J Clin Pract. 2020 Oct;74(10):e13575. doi: 10.1111/ijcp.13575.
Ntie-Kang F, Svozil D. An enumeration of natural products from microbial, marine and terrestrial sources. Physical Sciences Reviews. 2020;5(8). doi:10.1515/psr-2018-0121
Drápela S, Khirsariya P, van Weerden WM, Fedr R, Suchánková T, Búzová D, Červený J, Hampl A, Puhr M, Watson WR, Culig Z, Krejčí L, Paruch K, Souček K. The CHK1 inhibitor MU380 significantly increases the sensitivity of human docetaxel-resistant prostate cancer cells to gemcitabine through the induction of mitotic catastrophe. Mol Oncol. 2020 Oct;14(10):2487-2503. doi: 10.1002/1878-0261.12756.
Vojáčková P, Michalska L, Nečas M, Shcherbakov D, Böttger EC, Šponer J, Šponer JE, Švenda J. Stereocontrolled Synthesis of (-)-Bactobolin A. J Am Chem Soc. 2020 Apr 22;142(16):7306-7311. doi: 10.1021/jacs.0c01554.
Martín Moyano P, Němec V, Paruch K. Cdc-Like Kinases (CLKs): Biology, Chemical Probes, and Therapeutic Potential. Int J Mol Sci. 2020 Oct 13;21(20):7549. doi: 10.3390/ijms21207549.
Janoš J, Madea D, Mahvidi S, Mujawar T, Švenda J, Suchan J, Slavíček P, Klán P. Conformational Control of the Photodynamics of a Bilirubin Dipyrrinone Subunit: Femtosecond Spectroscopy Combined with Nonadiabatic Simulations. J Phys Chem A. 2020 Dec 17;124(50):10457-10471. doi: 10.1021/acs.jpca.0c08945.
Vašíček O, Fedr R, Skoroplyas S, Chalupa D, Sklenář M, Tharra PR, Švenda J, Kubala L. Natural pseurotins and analogs thereof inhibit activation of B-cells and differentiation into the plasma cells. Phytomedicine. 2020 Apr;69:153194. doi: 10.1016/j.phymed.2020.153194.
Madea D, Mahvidi S, Chalupa D, Mujawar T, Dvořák A, Muchová L, Janoš J, Slavíček P, Švenda J, Vítek L, Klán P. Wavelength-Dependent Photochemistry and Biological Relevance of a Bilirubin Dipyrrinone Subunit. J Org Chem. 2020 Oct 16;85(20):13015-13028. doi: 10.1021/acs.joc.0c01673.
Pelet A, Skopova V, Steuerwald U, Baresova V, Zarhrate M, Plaza JM, Hnizda A, Krijt M, Souckova O, Wibrand F, Andorsdóttir G, Joensen F, Sedlak D, Bleyer AJ, Kmoch S, Lyonnet S, Zikanova M. PAICS deficiency, a new defect of de novo purine synthesis resulting in multiple congenital anomalies and fatal outcome. Hum Mol Genet. 2019 Nov 15;28(22):3805-3814. doi: 10.1093/hmg/ddz237.
Pavlíčková V, Jurášek M, Rimpelová S, Záruba K, Sedlák D, Šimková M, Kodr D, Staňková E, Fähnrich J, Rottnerová Z, Bartůněk P, Lapčík O, Drašar P, Ruml T. Oxime-based 19-nortestosterone-pheophorbide a conjugate: bimodal controlled release concept for PDT. J Mater Chem B. 2019 Sep 18;7(36):5465-5477. doi: 10.1039/c9tb01301f.
Mrkvová Z, Uldrijan S, Pombinho A, Bartůněk P, Slaninová I. Benzimidazoles Downregulate Mdm2 and MdmX and Activate p53 in MdmX Overexpressing Tumor Cells. Molecules. 2019 Jun 7;24(11):2152. doi: 10.3390/molecules24112152.
Brennecke P, Rasina D, Aubi O, Herzog K, Landskron J, Cautain B, Vicente F, Quintana J, Mestres J, Stechmann B, Ellinger B, Brea J, Kolanowski JL, Pilarski R, Orzaez M, Pineda-Lucena A, Laraia L, Nami F, Zielenkiewicz P, Paruch K, Hansen E, von Kries JP, Neuenschwander M, Specker E, Bartunek P, Simova S, Leśnikowski Z, Krauss S, Lehtiö L, Bilitewski U, Brönstrup M, Taskén K, Jirgensons A, Lickert H, Clausen MH, Andersen JH, Vicent MJ, Genilloud O, Martinez A, Nazaré M, Fecke W, Gribbon P. EU-OPENSCREEN: A Novel Collaborative Approach to Facilitate Chemical Biology. SLAS Discov. 2019 Mar;24(3):398-413. doi: 10.1177/2472555218816276.
Temirgaziyev BS, Kučáková K, Baizhigit YA, Jurášek M, Džubák P, Hajdúch M, Dolenský B, Drašar PB, Tuleuov BI, Adekenov SM. Bioavailability and structural study of 20-hydroxyecdysone complexes with cyclodextrins. Steroids. 2019 Jul;147:37-41. doi: 10.1016/j.steroids.2018.11.007.
Bříza T, Králová J, Rimpelová S, Havlík M, Kaplánek R, Kejík Z, Martásek P, Mikula I, Džubák P, Hajdúch M, Ruml T, Král V. Pentamethinium salts as ligands for cancer: Sulfated polysaccharide co-receptors as possible therapeutic target. Bioorg Chem. 2019 Feb;82:74-85. doi: 10.1016/j.bioorg.2018.02.011.
Nowikow C, Fuerst R, Kauderer M, Dank C, Schmid W, Hajduch M, Rehulka J, Gurska S, Mokshyna O, Polishchuk P, Zupkó I, Dzubak P, Rinner U. Synthesis and biological evaluation of cis-restrained carbocyclic combretastatin A-4 analogs: Influence of the ring size and saturation on cytotoxic properties. Bioorg Med Chem. 2019 Oct 1;27(19):115032. doi: 10.1016/j.bmc.2019.07.048.
Polishchuk P, Kutlushina A, Bashirova D, Mokshyna O, Madzhidov T. Virtual Screening Using Pharmacophore Models Retrieved from Molecular Dynamic Simulations. Int J Mol Sci. 2019 Nov 20;20(23):5834. doi: 10.3390/ijms20235834.
de Bruyn Kops C, Stork C, Šícho M, Kochev N, Svozil D, Jeliazkova N, Kirchmair J. GLORY: Generator of the Structures of Likely Cytochrome P450 Metabolites Based on Predicted Sites of Metabolism. Front Chem. 2019 Jun 12;7:402. doi: 10.3389/fchem.2019.00402.
Šícho M, Stork C, Mazzolari A, de Bruyn Kops C, Pedretti A, Testa B, Vistoli G, Svozil D, Kirchmair J. FAME 3: Predicting the Sites of Metabolism in Synthetic Compounds and Natural Products for Phase 1 and Phase 2 Metabolic Enzymes. J Chem Inf Model. 2019 Aug 26;59(8):3400-3412. doi: 10.1021/acs.jcim.9b00376.
Boudny M, Zemanova J, Khirsariya P, Borsky M, Verner J, Cerna J, Oltova A, Seda V, Mraz M, Jaros J, Jaskova Z, Spunarova M, Brychtova Y, Soucek K, Drapela S, Kasparkova M, Mayer J, Paruch K, Trbusek M. Novel CHK1 inhibitor MU380 exhibits significant single-agent activity in TP53-mutated chronic lymphocytic leukemia cells. Haematologica. 2019 Dec;104(12):2443-2455. doi: 10.3324/haematol.2018.203430.
Chirackal Manavalan AP, Pilarova K, Kluge M, Bartholomeeusen K, Rajecky M, Oppelt J, Khirsariya P, Paruch K, Krejci L, Friedel CC, Blazek D. CDK12 controls G1/S progression by regulating RNAPII processivity at core DNA replication genes. EMBO Rep. 2019 Sep;20(9):e47592. doi: 10.15252/embr.201847592.
Němec V, Hylsová M, Maier L, Flegel J, Sievers S, Ziegler S, Schröder M, Berger BT, Chaikuad A, Valčíková B, Uldrijan S, Drápela S, Souček K, Waldmann H, Knapp S, Paruch K. Furo[3,2-b]pyridine: A Privileged Scaffold for Highly Selective Kinase Inhibitors and Effective Modulators of the Hedgehog Pathway. Angew Chem Int Ed Engl. 2019 Jan 21;58(4):1062-1066. doi: 10.1002/anie.201810312.
Králová J, Jurášek M, Krčová L, Dolenský B, Novotný I, Dušek M, Rottnerová Z, Kahle M, Drašar P, Bartůněk P, Král V. Heterocyclic sterol probes for live monitoring of sterol trafficking and lysosomal storage disorders. Sci Rep. 2018 Sep 26;8(1):14428. doi: 10.1038/s41598-018-32776-6.
Oltova J, Jindrich J, Skuta C, Svoboda O, Machonova O, Bartunek P. Zebrabase: An Intuitive Tracking Solution for Aquatic Model Organisms. Zebrafish. 2018 Dec;15(6):642-647. doi: 10.1089/zeb.2018.1609.
Jurášek M, Černohorská M, Řehulka J, Spiwok V, Sulimenko T, Dráberová E, Darmostuk M, Gurská S, Frydrych I, Buriánová R, Ruml T, Hajdúch M, Bartůněk P, Dráber P, Džubák P, Drašar PB, Sedlák D. Estradiol dimer inhibits tubulin polymerization and microtubule dynamics. J Steroid Biochem Mol Biol. 2018 Oct;183:68-79. doi: 10.1016/j.jsbmb.2018.05.008.
Brustikova K, Sedlak D, Kubikova J, Skuta C, Solcova K, Malik R, Bartunek P, Svoboda P. Cell-Based Reporter System for High-Throughput Screening of MicroRNA Pathway Inhibitors and Its Limitations. Front Genet. 2018 Feb 27;9:45. doi: 10.3389/fgene.2018.00045.
Rárová L, Sedlák D, Oklestkova J, Steigerová J, Liebl J, Zahler S, Bartůněk P, Kolář Z, Kohout L, Kvasnica M, Strnad M. The novel brassinosteroid analog BR4848 inhibits angiogenesis in human endothelial cells and induces apoptosis in human cancer cells in vitro. J Steroid Biochem Mol Biol. 2018 Apr;178:263-271. doi: 10.1016/j.jsbmb.2018.01.005.
Horký P, Voráčová M, Konečná K, Sedlák D, Bartůněk P, Vacek J, Kuneš J, Pour M. Nontoxic combretafuranone analogues with high in vitro antibacterial activity. Eur J Med Chem. 2018 Jan 1;143:843-853. doi: 10.1016/j.ejmech.2017.11.078.
Kutlushina A, Khakimova A, Madzhidov T, Polishchuk P. Ligand-Based Pharmacophore Modeling Using Novel 3D Pharmacophore Signatures. Molecules. 2018 Nov 27;23(12):3094. doi: 10.3390/molecules23123094.
Pokorny J, Krajcovicova S, Hajduch M, Holoubek M, Gurska S, Dzubak P, Volna T, Popa I, Urban M. Triterpenic azines, a new class of compounds with selective cytotoxicity to leukemia cells CCRF-CEM. Future Med Chem. 2018 Mar 1;10(5):483-491. doi: 10.4155/fmc-2017-0171
Šesták S, Bella M, Klunda T, Gurská S, Džubák P, Wöls F, Wilson IBH, Sladek V, Hajdúch M, Poláková M, Kóňa J. N-Benzyl Substitution of Polyhydroxypyrrolidines: The Way to Selective Inhibitors of Golgi α-Mannosidase II. ChemMedChem. 2018 Feb 20;13(4):373-383. doi: 10.1002/cmdc.201700607
Krajcovicova S, Stankova J, Dzubak P, Hajduch M, Soural M, Urban M. A Synthetic Approach for the Rapid Preparation of BODIPY Conjugates and their use in Imaging of Cellular Drug Uptake and Distribution. Chemistry. 2018 Apr 3;24(19):4957-4966. doi: 10.1002/chem.201706093.
Havel S, Khirsariya P, Akavaram N, Paruch K, Carbain B. Preparation of 3,4-Substituted-5-Aminopyrazoles and 4-Substituted-2-Aminothiazoles. J Org Chem. 2018 Dec 21;83(24):15380-15405. doi: 10.1021/acs.joc.8b02655.
Vojáčková P, Chalupa D, Prieboj J, Nečas M, Švenda J. Enantioselective Conjugate Additions of 2-Alkoxycarbonyl-3(2 H)-furanones. Org Lett. 2018 Nov 16;20(22):7085-7089. doi: 10.1021/acs.orglett.8b03039
Kaushik S, Marques SM, Khirsariya P, Paruch K, Libichova L, Brezovsky J, Prokop Z, Chaloupkova R, Damborsky J. Impact of the access tunnel engineering on catalysis is strictly ligand-specific. FEBS J. 2018 Apr;285(8):1456-1476. doi: 10.1111/febs.14418.
the November 2017 issue of Chemické listy dedicated to computational drug design from CZ-OPENSCREEN authors.
Grekov I, Pombinho AR, Kobets T, Bartůněk P, Lipoldová M. Calcium Ionophore, Calcimycin, Kills Leishmania Promastigotes by Activating Parasite Nitric Oxide Synthase. Biomed Res Int. 2017;2017:1309485. doi: 10.1155/2017/1309485.
Skuta C, Popr M, Muller T, Jindrich J, Kahle M, Sedlak D, Svozil D, Bartunek P. Probes &Drugs portal: an interactive, open data resource for chemical biology. Nat Methods. 2017 Jul 28;14(8):759-760. doi: 10.1038/nmeth.4365.
Seydlová G, Pohl R, Zborníková E, Ehn M, Šimák O, Panova N, Kolář M, Bogdanová K, Večeřová R, Fišer R, Šanderová H, Vítovská D, Sudzinová P, Pospíšil J, Benada O, Křížek T, Sedlák D, Bartůněk P, Krásný L, Rejman D. Lipophosphonoxins II: Design, Synthesis, and Properties of Novel Broad Spectrum Antibacterial Agents. J Med Chem. 2017 Jul 27;60(14):6098-6118. doi: 10.1021/acs.jmedchem.7b00355.
Kralova J, Kolar M, Kahle M, Truksa J, Lettlova S, Balusikova K, Bartunek P. Glycol porphyrin derivatives and temoporfin elicit resistance to photodynamic therapy by different mechanisms. Sci Rep. 2017 Mar 15;7:44497. doi: 10.1038/srep44497.
Jurášek M, Džubák P, Rimpelová S, Sedlák D, Konečný P, Frydrych I, Gurská S, Hajdúch M, Bogdanová K, Kolář M, Müller T, Kmoníčková E, Ruml T, Harmatha J, Drašar PB. Trilobolide-steroid hybrids: Synthesis, cytotoxic and antimycobacterial activity. Steroids. 2017 Jan;117:97-104. doi: 10.1016/j.steroids.2016.08.011.
Agrawal K, Das V, Otmar M, Krečmerová M, Džubák P, Hajdúch M. Cell-based DNA demethylation detection system for screening of epigenetic drugs in 2D, 3D, and xenograft models. Cytometry A. 2017 Feb;91(2):133-143. doi: 10.1002/cyto.a.23004.
Voller J, Béres T, Zatloukal M, Kaminski PA, Niemann P, Doležal K, Džubák P, Hajdúch M, Strnad M. The natural cytokinin 2OH3MeOBAR induces cell death by a mechanism that is different from that of the “classical” cytokinin ribosides. Phytochemistry. 2017 Apr;136:156-164. doi: 10.1016/j.phytochem.2017.01.004.
Voršilák M, Svozil D. Nonpher: computational method for design of hard-to-synthesize structures. J Cheminform. 2017 Mar 20;9(1):20. doi: 10.1186/s13321-017-0206-2.
Šícho M, de Bruyn Kops C, Stork C, Svozil D, Kirchmair J. FAME 2: Simple and Effective Machine Learning Model of Cytochrome P450 Regioselectivity. J Chem Inf Model. 2017 Aug 28;57(8):1832-1846. doi: 10.1021/acs.jcim.7b00250.
Paculová H, Kramara J, Šimečková Š, Fedr R, Souček K, Hylse O, Paruch K, Svoboda M, Mistrík M, Kohoutek J. BRCA1 or CDK12 loss sensitizes cells to CHK1 inhibitors. Tumour Biol. 2017 Oct;39(10):1010428317727479. doi: 10.1177/1010428317727479.
Herůdková J, Paruch K, Khirsariya P, Souček K, Krkoška M, Vondálová Blanářová O, Sova P, Kozubík A, Hyršlová Vaculová A. Chk1 Inhibitor SCH900776 Effectively Potentiates the Cytotoxic Effects of Platinum-Based Chemotherapeutic Drugs in Human Colon Cancer Cells. Neoplasia. 2017 Oct;19(10):830-841. doi: 10.1016/j.neo.2017.08.002.
Samadder P, Suchánková T, Hylse O, Khirsariya P, Nikulenkov F, Drápela S, Straková N, Vaňhara P, Vašíčková K, Kolářová H, Binó L, Bittová M, Ovesná P, Kollár P, Fedr R, Ešner M, Jaroš J, Hampl A, Krejčí L, Paruch K, Souček K. Synthesis and Profiling of a Novel Potent Selective Inhibitor of CHK1 Kinase Possessing Unusual N-trifluoromethylpyrazole Pharmacophore Resistant to Metabolic N-dealkylation. Mol Cancer Ther. 2017 Sep;16(9):1831-1842. doi: 10.1158/1535-7163.MCT-17-0018.
Maier L, Khirsariya P, Hylse O, Adla SK, Černová L, Poljak M, Krajčovičová S, Weis E, Drápela S, Souček K, Paruch K. Diastereoselective Flexible Synthesis of Carbocyclic C-Nucleosides. J Org Chem. 2017 Apr 7;82(7):3382-3402. doi: 10.1021/acs.joc.6b02594.
Nekardová M, Vymětalová L, Khirsariya P, Kováčová S, Hylsová M, Jorda R, Kryštof V, Fanfrlík J, Hobza P, Paruch K. Structural Basis of the Interaction of Cyclin-Dependent Kinase 2 with Roscovitine and Its Analogues Having Bioisosteric Central Heterocycles. Chemphyschem. 2017 Apr 5;18(7):785-795. doi: 10.1002/cphc.201601319.
Hylsová M, Carbain B, Fanfrlík J, Musilová L, Haldar S, Köprülüoğlu C, Ajani H, Brahmkshatriya P S, Jorda R, Kryštof V, Hobza P, Echalier A, Paruch K, Lepšík M. Explicit Treatment of Active-site Waters Enhances Quantum Mechanical/Implicit Solvent Scoring: Inhibition of CDK2 by new Pyrazolo[1.5-a]Pyrimidines. Eur J Med Chem. 2017 Jan 27;126:1118-1128. doi: 10.1016/j.ejmech.2016.12.023
Hylse, O.; Maier, L.; Kučera, R.; Perečko, T.; Svobodová, A.; Kubala, L.; Paruch, K.; Švenda, J.* A concise synthesis of forskolin. Angew. Chem. Int. Ed. 2017 Oct 2;56(41):12586-12589. doi: 10.1002/anie.201706809
Brezaniova I, Hruby M, Kralova J, Kral V, Cernochova Z, Cernoch P, Slouf M, Kredatusova J, Stepanek P. Temoporfin-loaded 1-tetradecanol-based thermoresponsive solid lipid nanoparticles for photodynamic therapy. J Control Release. 2016 Nov 10;241:34-44. doi: 10.1016/j.jconrel.2016.09.009.
Biedermann D, Buchta M, Holečková V, Sedlák D, Valentová K, Cvačka J, Bednárová L, Křenková A, Kuzma M, Škuta C, Peikerová Ž, Bartůněk P, Křen V. Silychristin: Skeletal Alterations and Biological Activities. J Nat Prod. 2016 Dec 23;79(12):3086-3092. doi: 10.1021/acs.jnatprod.6b00750.
Felker A, Nieuwenhuize S, Dolbois A, Blazkova K, Hess C, Low LW, Burger S, Samson N, Carney TJ, Bartunek P, Nevado C, Mosimann C. In Vivo Performance and Properties of Tamoxifen Metabolites for CreERT2 Control. PLoS One. 2016 Apr 14;11(4):e0152989. doi: 10.1371/journal.pone.0152989.
Rárová L, Steigerová J, Kvasnica M, Bartůněk P, Křížová K, Chodounská H, Kolář Z, Sedlák D, Oklestkova J, Strnad M. Structure activity relationship studies on cytotoxicity and the effects on steroid receptors of AB-functionalized cholestanes. J Steroid Biochem Mol Biol. 2016 May;159:154-69. doi: 10.1016/j.jsbmb.2016.03.017.
Hezova R, Kovarikova A, Srovnal J, Zemanova M, Harustiak T, Ehrmann J, Hajduch M, Sachlova M, Svoboda M, Slaby O. MiR-205 functions as a tumor suppressor in adenocarcinoma and an oncogene in squamous cell carcinoma of esophagus. Tumour Biol. 2016 Jun;37(6):8007-18. doi: 10.1007/s13277-015-4656-8.
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Das V, Fürst T, Gurská S, Džubák P, Hajdúch M. Reproducibility of Uniform Spheroid Formation in 384-Well Plates: The Effect of Medium Evaporation. J Biomol Screen. 2016 Oct;21(9):923-30. doi: 10.1177/1087057116651867.
Schadich E, Hlaváč J, Volná T, Varanasi L, Hajdúch M, Džubák P. Effects of Ginger Phenylpropanoids and Quercetin on Nrf2-ARE Pathway in Human BJ Fibroblasts and HaCaT Keratinocytes. Biomed Res Int. 2016;2016:2173275. doi: 10.1155/2016/2173275.
Zemanova J, Hylse O, Collakova J, Vesely P, Oltova A, Borsky M, Zaprazna K, Kasparkova M, Janovska P, Verner J, Kohoutek J, Dzimkova M, Bryja V, Jaskova Z, Brychtova Y, Paruch K, Trbusek M. Chk1 inhibition significantly potentiates activity of nucleoside analogs in TP53-mutated B-lymphoid cells. Oncotarget. 2016 Sep 20;7(38):62091-62106. doi: 10.18632/oncotarget.11388.
Hill N, Paruch K, Švenda J. Late-stage Annulative Convergency in Natural Product Synthesis. Tetrahedron. 2016 Jun 16;72(24):3345-68. doi: 10.1016/j.tet.2016.04.004
Bříza T, Králová J, Dolenský B, Rimpelová S, Kejík Z, Ruml T, Hajdúch M, Džubák P, Mikula I, Martásek P, Poučková P, Král V. Striking antitumor activity of a methinium system with incorporated quinoxaline unit obtained by spontaneous cyclization. Chembiochem. 2015 Mar 2;16(4):555-8. doi: 10.1002/cbic.201402662.
Kaplánek R, Jakubek M, Rak J, Kejík Z, Havlík M, Dolenský B, Frydrych I, Hajdúch M, Kolář M, Bogdanová K, Králová J, Džubák P, Král V. Caffeine-hydrazones as anticancer agents with pronounced selectivity toward T-lymphoblastic leukaemia cells. Bioorg Chem. 2015 Jun;60:19-29. doi: 10.1016/j.bioorg.2015.03.003.
Kaplánek R, Havlík M, Dolenský B, Rak J, Džubák P, Konečný P, Hajdúch M, Králová J, Král V. Synthesis and biological activity evaluation of hydrazone derivatives based on a Tröger's base skeleton. Bioorg Med Chem. 2015 Apr 1;23(7):1651-9. doi: 10.1016/j.bmc.2015.01.029.
Liegertová M, Pergner J, Kozmiková I, Fabian P, Pombinho AR, Strnad H, Pačes J, Vlček Č, Bartůněk P, Kozmik Z. Cubozoan genome illuminates functional diversification of opsins and photoreceptor evolution. Sci Rep. 2015 Jul 8;5:11885. doi: 10.1038/srep11885. Erratum in: Sci Rep. 2015;5:14396.
Čech P, Hoksza D, Svozil D. MultiSETTER: web server for multiple RNA structure comparison. BMC Bioinformatics. 2015 Aug 12;16:253. doi: 10.1186/s12859-015-0696-8
Hoksza D, Svozil D. Multiple 3D RNA Structure Superposition Using Neighbor Joining. IEEE/ACM Trans Comput Biol Bioinform. 2015 May-Jun;12(3):520-30. doi: 10.1109/TCBB.2014.2351810.
Amaro M, Brezovský J, Kováčová S, Sýkora J, Bednář D, Němec V, Lišková V, Kurumbang NP, Beerens K, Chaloupková R, Paruch K, Hof M, Damborský J. Site-specific analysis of protein hydration based on unnatural amino acid fluorescence. J Am Chem Soc. 2015 Apr 22;137(15):4988-92. doi: 10.1021/jacs.5b01681.
Kováčová S, Adla SK, Maier L, Babiak M, Mizushina Y, Paruch K. Synthesis of carbocyclic analogs of dehydroaltenusin: Identification of a stable inhibitor of calf DNA polymerase α. Tetrahedron. 2015 Oct 7;71(40):7575-82. doi: 10.1016/j.tet.2015.08.005
Skuta C, Bartůněk P, Svozil D. InCHlib - interactive cluster heatmap for web applications. J Cheminform. 2014 Sep 17;6(1):44. doi: 10.1186/s13321-014-0044-4.
Hoksza D, Skoda P, Voršilák M, Svozil D. Molpher: a software framework for systematic chemical space exploration. J Cheminform. 2014 Mar 21;6(1):7. doi: 10.1186/1758-2946-6-7.
Tumova L, Pombinho AR, Vojtechova M, Stancikova J, Gradl D, Krausova M, Sloncova E, Horazna M, Kriz V, Machonova O, Jindrich J, Zdrahal Z, Bartunek P, Korinek V. Monensin inhibits canonical Wnt signaling in human colorectal cancer cells and suppresses tumor growth in multiple intestinal neoplasia mice. Mol Cancer Ther. 2014 Apr;13(4):812-22. doi: 10.1158/1535-7163.
Podolska K, Sedlak D, Bartunek P, Svoboda P. Fluorescence-based high-throughput screening of dicer cleavage activity. J Biomol Screen. 2014 Mar;19(3):417-26. doi: 10.1177/1087057113497400.
Nauš P, Caletková O, Konečný P, Džubák P, Bogdanová K, Kolář M, Vrbková J, Slavětínská L, Tloušt'ová E, Perlíková P, Hajdúch M, Hocek M. Synthesis, cytostatic, antimicrobial, and anti-HCV activity of 6-substituted 7-(het)aryl-7-deazapurine ribonucleosides. J Med Chem. 2014 Feb 13;57(3):1097-110. doi: 10.1021/jm4018948.
Snášel J, Nauš P, Dostál J, Hnízda A, Fanfrlík J, Brynda J, Bourderioux A, Dušek M, Dvořáková H, Stolaříková J, Zábranská H, Pohl R, Konečný P, Džubák P, Votruba I, Hajdúch M, Rezáčová P, Veverka V, Hocek M, Pichová I. Structural basis for inhibition of mycobacterial and human adenosine kinase by 7-substituted 7-(Het)aryl-7-deazaadenine ribonucleosides. J Med Chem. 2014 Oct 23;57(20):8268-79. doi: 10.1021/jm500497v.
Mattová J, Poučková P, Kučka J, Skodová M, Vetrík M, Stěpánek P, Urbánek P, Petřík M, Nový Z, Hrubý M. Chelating polymeric beads as potential therapeutics for Wilson's disease. Eur J Pharm Sci. 2014 Oct 1;62:1-7. doi: 10.1016/j.ejps.2014.05.002.
Das V, Sim DA, Miller JH. Effect of taxoid and nontaxoid site microtubule-stabilizing agents on axonal transport of mitochondria in untransfected and ECFP-htau40-transfected rat cortical neurons in culture. J Neurosci Res. 2014 Sep;92(9):1155-66. doi: 10.1002/jnr.23394.
Messina I, Popa I, Maier V, Soural M. Solid-phase synthesis of 5-noranagrelide derivatives. ACS Comb Sci. 2014 Jan 13;16(1):33-8. doi: 10.1021/co4001315.
McMaster C, Fülöpová V, Popa I, Grepl M, Soural M. Solid-phase synthesis of anagrelide sulfonyl analogues. ACS Comb Sci. 2014 May 12;16(5):221-4. doi: 10.1021/co400119c.
Cankařová N, La Venia A, Krchňák V. Polymer-supported stereoselective synthesis of tetrahydrobenzopyrazino-thiadiazinone dioxides via N-sulfonyl iminiums. ACS Comb Sci. 2014 Jun 9;16(6):293-302. doi: 10.1021/co5000163.
Motyka K, Stýskala J, Cankař P, Hlaváč J. Fluorescence properties of selected benzo[c]phenanthridines. J Fluoresc. 2014 Jul;24(4):1177-82. doi: 10.1007/s10895-014-1398-8.
Kadrić J, Motyka K, Džubák P, Hajdúch M, Soural M. Synthesis, cytotoxic activity, and fluorescence properties of a set of novel 3-hydroxyquinolin-4(1H)-ones. Tetrahedron Lett. 2014 Jun 25;55(26):3592-5. doi: 10.1016/j.tetlet.2014.04.121
Ventosa-Andrés P, Hradilová L, Krchňák V. Privileged structures as peptide backbone constraints: polymer-supported stereoselective synthesis of benzimidazolinopiperazinone peptides. ACS Comb Sci. 2014 Jul 14;16(7):359-66. doi: 10.1021/co500023k.
Schneider B, Cerný J, Svozil D, Cech P, Gelly JC, de Brevern AG. Bioinformatic analysis of the protein/DNA interface. Nucleic Acids Res. 2014 Mar;42(5):3381-94. doi: 10.1093/nar/gkt1273.
Labroli MA, Dwyer MP, Popovici-Muller J, Pu Q, Richard J, Rosner K, Paruch K, Guzi TJ. Syntheses of 5´-amino-2´,5´-dideoxy-2´,2´-difluorocytidine derivatives as novel anticancer nucleoside analogs. Tetrahedron Lett. 2014 Jan 15;55(3):598-602. doi: 10.1016/j.tetlet.2013.11.018
Maier L, Hylse O, Necas M, Trbusek M, Ytre-Arne M, Dalhus B, Bjoras M, Paruch K. New carbocyclic nucleosides: Synthesis of carbocyclic pseudoisocytidine and its analogs. Tetrahedron Lett. 2014 Jul 2;55(27):3713-6. doi: 10.1016/j.tetlet.2014.05.030
Beranova L, Pombinho AR, Spegarova J, Koc M, Klanova M, Molinsky J, Klener P, Bartunek P, Andera L. The plant alkaloid and anti-leukemia drug homoharringtonine sensitizes resistant human colorectal carcinoma cells to TRAIL-induced apoptosis via multiple mechanisms. Apoptosis. 2013 Jun;18(6):739-50. doi: 10.1007/s10495-013-0823-9.
Sedlák D, Eignerová B, Dračínský M, Janoušek Z, Bartůněk P, Kotora M. Synthesis and evaluation of 17 alpha-(carboranylalkyl)estradiols as ligands for estrogen receptors alpha and beta. J Organometal Chem. 2013 Dec 1; 747:178-83. doi: 10.1016/j.jorganchem.2013.06.013
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Brahmkshatriya PS, Dobeš P, Fanfrlik J, Rezáç J, Paruch K, Bronowska A, Lepšík M, Hobza P. Quantum mechanical scoring: structural and energetic insights into cyclin-dependent kinase 2 inhibition by pyrazolo[1,5-a]pyrimidines. Curr Comput Aided Drug Des. 2013 Mar;9(1):118-29. doi: 10.2174/1573409911309010011.
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Alquicer G, Sedlák D, Byun Y, Pavlícek J, Stathis M, Rojas C, Slusher B, Pomper MG, Bartunek P, Barinka C. Development of a high-throughput fluorescence polarization assay to identify novel ligands of glutamate carboxypeptidase II. J Biomol Screen. 2012 Sep;17(8):1030-40. doi: 10.1177/1087057112451924.
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