Compound collection

Chemical libraries (or chemical compound collections) are one of the essential components for research areas of chemical biology and medicinal chemistry. Chemical libraries are databases of small organic compounds, usable in drug discovery and other industrial processes. For the selection of new compounds we employ advanced cheminformatic tools. High degree of chemical diversity is one of the fundamental requirements for chemical library used in high throughput screening (HTS). Conversely, we sort and compile the compounds with similar properties (structural, physicochemical, pharmacological, etc.) into smaller, focused sub-libraries also called subsets. By employing of these specialized subsets we can achieve higher economical and time effectivity of the biological activity testing.

Currently, the biggest part of our library is occupied by the samples from custom picked diversity sets as:

Enamine Diverse set (45 000)

ChemBridge Diverse set (10 000)

ChemBridge DIVERSet™  (10 000)

Another substantial part of the library is occupied by commercially available sets of bioactive substances and proved drugs as:

Custom picked Bioactive set 2018 (1 822 best-in-class probes and drugs)

Sigma Lopac (1 284)

Prestwick Chemical Library (1 120)

NIH Clinical Trials (446)

Nuclear Receptor Signaling Ligand set (558)

GSK Published Kinase Inhibitors set (360)

Diverse Natural Products (1 080)

Cayman Prostaglandins and Fatty acids (321)

 

Collections of proprietary chemical substances in form of smaller libraries or individual compounds form another valuable part of our library. These samples are usually obtained in means of collaboration with variety of chemical laboratories and institutes, where small molecules are synthesized.

Proprietary set Academic/Industrial (24 000)

 

Our collection grows dynamically and every day the sample count is expanding.

The highest possible quality of the individual samples in the library is essential for providing reliable and reproducible screening results. Compound integrity in time is assured by optimal storage conditions (-20 °C, nitrogen atmosphere) and gentle handling conditions (limiting of freeze-thaw cycles, limited exposure to atmospheric environment, protection of light-sensitive samples from daylight, etc.). Identity of the chemical samples is assured by following strict rules for registration and handling, which contain a series of checkpoints to prevent unwanted sample confusion. Quality (identity, purity) of the individual samples in the library is surveyed by LC-MS on regular basis. Quality Control (QC) of all new compounds entering the collection, as well as existing compounds and of all hits is performed.